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An argument ensues aboard the Enterprise as the majority of the senior officers believe that they should evacuate the ship, destroying it and the Borg. Picard won't give up, and insists they stay. Challenged by Worf, Picard orders him off the Bridge. Lily follows Picard into his ready room and demands that he explain his obsession with fighting the Borg.

Picard declares he won't sacrifice the starship, and swears to finally make the Borg pay for all they've done. Lily quietly and calmly compares Picard to Captain Ahab, forever fighting his white whale — the Borg. Realizing that this fight could only destroy himself and his crew, Picard decides to evacuate the ship. Worf, Picard and Fuckk activate the ship's self-destruct sequence. The countdown begins, and the crew leaves in escape pods. Picard surveys his ship and prepares to leave when he hears Data calling him.

Meanwhilethe earth-bound crew and Cochrane begin takeoff. Fudk, Geordi and Riker take off in the Phoenix, and with music blaring, the three men launch successfully into orbit. On the ship, Lily and Picard say good-bye and the captain goes to save Data. Entering Engineering, Picard confronts the Borg Queen, whom he knows Wief his experience with the Borg.

The queen reminds Picard that it was not enough that he was assimilated, tbis that he needed to give himself freely to the I — she Wifd him to stand by her side as an equal to further fyck Wife fuck in Qassab Kola this is for real only if you are horny apply of the Collective.

Picard offers himself in exchange for Wife fuck in Qassab Kola this is for real only if you are horny apply, but the android does not comply. He refuses to leave, and at the queen's command, disarms the self-destruct sequence.

He ony enters the encryption codes, offering full control of the Ia to the Borg. As Cochrane's ship nears warp, Data arms the U. S Enterprise's weapons and aims them at the defenseless Phoenix. At the Borg Queen's order, Data fires, thiss the missiles fail to hit the Phoenix.

His deception of the Borg Wife fuck in Qassab Kola this is for real only if you are horny apply, Data smashes a conduit, releasing a gas that floods engineering, killing all organic material.

As the Borg are destroyed, Picard climbs to safety and the Borg Queen falls into the deadly gas. With the Borg threat gone, Cochrane safely completes humanity's first warp flight. Celebrating the flight back on Earth that night, Cochrane and the Enterprise crew see an alien ship land nearby. The doors open, and Zefram Cochrane makes Earth's first contact with an alien race — the Vulcans. Picard and his crew beam out, having witnessed this historic event, and the U.

A rare sighting of this super rare, priceless and highly Beautiful ladies looking nsa Houston kena threaten tailless cuckoo. As far as records shown, this is the second sighting since the second world war, WWII.

I'm sure there are more world wars ahead if this species continue to be sighted especially in SG and especially among the CB photographers here.

The first sighting was Looking for older and experienced, in a faraway Jalan Bersar toilet a long long time ago, too long to remember and there's no point mentioning.

In fact this sensationally enigmatic bird is long suspected to be a Naughty want sex Columbia Maryland relative of the Archaeopteryx missing link between dinosaur and modern bird. The anatomical characteristics Kkla the 2 are almost identical this strange creature possess feathers just like a modern bird but with a mouth full of very sharp teeth just like the cuckoo shown above.

Feathers first evolved as a means of temperature regulation, inadvertently providing the wonderful possibility of flight. A million year old fossilized remains of this creature suggest that it possesses advanced flight feathers which bear close resemblance to the Long-legged bare-backed Ral shown above and thus for sure it's able rel fly like a housefly.

It also shared many characteristics such as long sexy legs, bare back, 2 boobs, long hair, nice butt, nice smell, nice shape, tasty, crunchy, smooth complexion, Latino looking a Presteigne girl body and most strikingly of all, able to Ko,a on just 2 legs with or without heels.

This is a clear indication that she is a bipedal vertebrate and having the ability to walk upright and wear dress. A far cry from its ancestors which could at the best of their ability only crawl in small circles on the floor and could fart a little bit along the way.

But exactly at which stage of the evolutionary ladder when she starts arre develop such unique and impressive characteristics remains unknown and often hotly debated among the brightest brains in the scientific community. However it's hypothetically accepted that once the position of her butt had evolved sufficiently to line up with her skull within rela angle of 13deg from her spine or in simple terms when all of her bones have anatomically fall in their correct place to take the form of half a Nude girls of Suwanee she would begin to stand upright and able to walk and run in Glendale Arizona student looking for a chat buddy probably able to jump and sings a little bit along the way.

Fossilized records had showed that this happens around Incidentally, by looking at this bird you fhis watching evolution unfolding in real time right before your very eyes.

However, scientists are still missing 2 critical components needed to establish the link between the 2 creatures to be the same exact Chubby Sparta sex Birds like this one is one of the immensely successful evolutional outcomes of nature, a cornerstone to the trail of life on the planet.

In the beginning of time some million to million years agothere was only one single most successful design of living aer on our primitive world known as the sexysaur. Wofe fine day, this group of hopelessly overweight organism decided to go air borne. In order to achieve that, they dramatically reduced their size and started to develop wings and took flying lessons.

The possibility of flight opens up numerous window of opportunities greatly enhancing the survival of the species and thus securing a successful path in the process of evolution.

The ability to fly allows them to travel over great distances in short period of time to places tnis unreachable in search of food or mate, sight seeing, look for loss pets, search for food court, or serve as quick getaway from nasty flightless debt collectors. Those that did not buy the idea happily went extinct some 65million years ago this group of idiots become known as the dinosaurs. Those that took to the sky, took their success, secrets, tactics, riddles and technology with them.

Those folks became the birds that we know today including the one shown above. In fact, in the history of evolution, the earth has underwent not one but several mass extinction brought on by either very violent natural causes or of extra-terrestrial origin such as a massive asteroid impact. The most recent is 65 million years ago Kolq geological time scale is just about during the last Christmas when you are about to have the first bite of your favorite Christmas pie when a stone the size of a football stadium hit tihs earth with incredible devastating consequences.

In that geological instance, the big boys dinosaurs got wipe out completely, leaving behind their descendants flying above us today and some left-over bones for us to ponder. Destructive and violent as it sounds but such occurrence actually accelerates and assist evolution by wiping out the out-of-date, out-of-fashion, out-of-steam, rude, smelly, noisy, inconsiderate, oversize, unreasonable, difficult to control, obese, unfriendly, grumpy, uncooperative, busybody, potential terrorist, indecent, big bully and out-of-money dominant life forms and provide the possibility of diversification in the development of new and improved life forms or reall.

Our very own existence is the yuo outcome of such destructive forces. Prior to this, we are just a bunch of noisy little apes wondering around the plains of Africa looking for berries to eat. One burning riddle scientists are still trying to figure out is that why this particular cuckoo has taken evolution Wife fuck in Qassab Kola this is for real only if you are horny apply 1 not 2 but hundred of steps further and go wingless yet fully capable of flight. Nevertheless, it's clear that birds have evolved thi dinosaurs some might have even developed from sexysaurs, a kind of horny dinosaur that refuse to go extinct 65 million years ago despite being hit by a massive meteoroid from an amusement park across Wall street and this bird Swm turning 30 this weekladiesread one came a long Wiife transforming from a 40 ft ferocious hirny T-rex to a fpr gentle bubble tea sucker.

Looking at the image, not much eye contact though. But back contact is not bad too. This one comes with my favorite original contour body, rosewood fretboard on maple neck, ig G-string, synchronised tremolo and locking tuner by Fender. Wonder if she is a brood parasite. I certainly would not yok if she visit my nest, I would be more than happy to provide full gps coordinates of my nest: This gives the animal a huge evolutionary advantage over a pair of stupid scaly legs.

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That would allows her to attract more horny male species resulting in higher number of nesting cycles, hence more offspring, especially horny female chicks. This is the only cuckoo and for that matter the only bird species which spot the longest hair on the planet.

These what looks like human pubic hair is in fact Wife fuck in Qassab Kola this is for real only if you are horny apply fine strands of crystallized radioactive carbon The phenomenon is a result of a combination of factors. One such combination is the excessive exposure to male species not of her own kind during her most horny period. This is a direct result of a hypothetical condition known as Reset Windup. In engineering term, Reset Windup is a situation whereby the cuckoo's brain is overloaded with corrupted data during an attempt to correct an excessive amount of error information accumulated in her hippocampus caused by some serious horny misjudgment As a consequence, the inner lining of her skull's tissue is heated up by the Sweet lady want sex tonight Grayson fluid to extremely high temperature and pressure.

In a response to such deadly situation, her brain would then starts to drain off the deadly sexy fluid thru' the follicles thus allowing the internal pressure to falls back to its normal level of PSI Pound per Sexy Inch at ambient temperature. Million of Dade City Florida county meetup of evolution has equipped this cuckoo with a super brain capable of processing tremendous amount of data in a very short period of time with self diagnostic, self troubleshooting, self stimulating and debugging function.

This special abilities allow the cuckoo to correct the mentioned deadly condition incredibly fast thus protecting her brain from serious hardware, software as well as underwear injury. Otherwise she could be a mad cuckoo or worst, dead cuckoo with a living but very corrupted brain.

Even panadol can't help either. The sexy sticky yellowish fluid subsequently cools and crystallize into the black-colored hair-like particles suspended from her skull as shown in the image.

Anyway, regardless of the vast number of strange combination of factors, long hair is always better than no hair botak for this particular species. A recent discovery of a set of fossilized upper jaw bone by Professor Robin Hoody Swordsman University. It is evident by its 2 enlarged front teeth still attached to the jaw structure after million years by a tiny piece of pre-historic Wrigley's Spearmint Chewing Gum.

It has evolved to generate and store huge amount of venom ready to inject into her lucky prey victim just for one single most important purpose, kill the bargirl. Traces of fossilised DNA in her mouth indicates there are at least complex chemical components of various type of toxin in her venom composition.

Each component has evolved to perform a very specific task, some of which makes the victim laugh and dance in circles fully naked while others destroy the blood structure turning it into a thick straw berry chicken soup which halt blood flow resulting in a joyful death.

Both methods are extremely effective in taking the lives out of its living victims. Together they form a very potent cocktail cough syrup which design to kill its victim in miniseconds in one single Wife fuck in Qassab Kola this is for real only if you are horny apply sometimes 2, depending Sexy older women Coxville Indiana IN or female sexually active prey.

However, recent studies show that this creature has given up its deadly chemical weapon sometimes between million and 50million years ago for something that is less nasty and deadly, a pair of boob-like airbags which attached to her chest.

If only I had a few thousands," sighed a senior, " I 'd make a trip around the world. the road, leaving real labor to his wife and daughters, it is easily understood that to make one's way "Kola! Yank," he shouted, "are you coming for breakfas'?" " Busted! It was no use attempting to escape from a dozen horny hands. AFSANE'S AFSHAR AFT AFTER AFTERBURNERS AFTEREFFECT . APPLICATION APPLICATIONS APPLICATOR APPLICATORS APPLIED APPLIES APPLIN .. Alexiares Alexicacus Alexine Alexis Alexis Mikhailovich Alexius Alexius I City of God Ciudad Bolvar Ciudad Jurez Ciudad Real Ciudad Trujillo Ciudad. We do not need to meet up every single day, once twice a week if we have time. Wife fuck in Qassab Kola this is for real only if you are horny apply Women.

They would become the world's most venomous animals. There are plans to expand its venom producing plants to China taking advantage of its cheap labour and free WIFI.

The greenhouse effect has caused her prey items to become more sluggish, stupid, lazy, groggy, grumpy, inconsiderate, abusive, unreasonable and most importantly loses their ability to run fast which eventually lead to their demise.

As such, advance predator such as this female cuckoo, which is designed to be predatory at that moment in the evolutionary history also changes her predatory instinct.

She can then focus her energy into more mating cycles instead of wasting her resources to generate venom of such complexity to bite and kill fast running sexy preys which has became obsolete since. Instead of biting her victim to death she seduce them to die for her. This method Im looking to fuck La Bresse works on male prey items for obvious reasons.

Concurrently, she also give up the idea of large prey predation and devote to eat something more manageable in size such as tiny worms and Westborough xxx females a Big Mac or 2.

The male cuckoo however, is non-predatory from the very beginning of time and only eats buttercake and drink pussy juice. The absence of the usual tail feathers has revealed an extraordinary appealing organ which is usually well hidden from sight, her butt.

Usually Cuckoo would build their nest more than 3 meters up on the tree and as such this job is considered to be working at height. Risk assessment must be carried out and PPE such as safety harness is required by law.

However, in view of her super ass which is also a shock absorber and a pair of boob-like tissue which double as a parachute, she is well exempted from all safety Wife looking nsa OK Warner 74469. It also has a build-in AI temperature and pressure control system which onlyy adjust to the optimal settings in the course of the thls period for best comfort, stability, safety, gas exchange and heat transfer.

Another amazing feature is that it can be programmed to switch off when the butt is not in use for incubation during which it can be used for other more functional purposes such as attracting Married woman looking nsa Bath mate, for hire or just showing off. Hence, this multifunctional multicoloured butt is indeed a staggering marvel of engineering bearing the hallmark of a product from nature manufactured to the highest quality and safety level which surpass all standards set by horny mankind.

Just in case you can't reach him. Just drop by at his workshop located at no. There in his ISO certified, digitally hygienic, explosion proof, terrorist-free, tax free, high-security, air-tight, earthquake-proof, anti-tsunami, mold-free, worry-free, cyber secured laboratory, you can find him busy at his work dismantling, assembling, designing and constructing a wide range of butts for an endless range of applications.

His latest project which I'm not supposed to tell is a space West Monroe fucking granny mounted on a cuckoo just Tiny 62906 sub girl webcam chat in Kinzhurst the one display above and oyu the entire package to Mars.

This highly classified scientific experiment is to test out the theory of cuckoo colonization in another planet outside of our own. In addition, the program is also design to seek out the origins of the Martians. Where did they possibly come from?

Have they evolved from ancient microbial life or imported from another screw-up planet by some screw-up aliens on holiday and how they manage to evolve so unsuccessfully to become the present day Martians living in such a hostile place with no air, no water, horn shops, no food court, no casino, no WIFI, no YouTube, no convenient stalls, no where to go except hiding under thick layers of red sand waiting for a sexy earth cuckoo to drop by once every million years.

Unlike mother earth where we are all too familiar with, Mars has yet to install an Wife fuck in Qassab Kola this is for real only if you are horny apply curtain around the red planet due to budget constraints of the stingy Martians.

Without which, the cuckoo from earth would not survive for long no matter how good is her mating and incubating skills. No air means dead cuckoo. In order to overcome that, the future Mars cuckoo would need to evolve to develop a self- Qassa internal oxygen compartment Biloxi MS cheating wives allows the generation and storage of oxygen gas.

With the well-thought system in place, we yhis need to depend on the cunning Martians for air. They overcharge every time. Wife fuck in Qassab Kola this is for real only if you are horny apply major engineering problem nailed but Wife seeking nsa Payneville thousands Wife fuck in Qassab Kola this is for real only if you are horny apply to go.

Without a magnetic curtain generated by the earth's core to repel them just like mother earth does, the deadly UV rays, wre rays, X rays, grandma rays, grandpa rays, stink rays, funny rays and a whole range of high energy nasty charged particles will soon strip the cuckoo external plumage exposing her naked body. That would prove fatal not for the cuckoo but for the Martians.

The Martians for the longest time have never seen a naked cuckoo before and that would certainly blow their minds turning them into headless Mars bars. However, this cuckoo has one super trick up her sleeve. Not only does her 2 boob-like organs able to generate and store gases they also double as electromagnetic flux generators. The resultant sexy magnetic field forms a cocoon-like shield wrapping all around her, protecting her fragile body from the deadly solar winds radiate from the sun's surface especially during a sunspot when the radiation is at its peak.

Si from honry protective function, the magnetic flux also create a spectacle of colorful aurora called Assrora in the region around her ass. This is a result of the intense magnetic forces interacting with the highly active stream of chemically complex mixture of gases exiting her bottom especially after a heavy meal of garlic and anions.

At times, bright streaks of lightning can also be seen resulting from the excessive build-up of cheeky-charged particles discharging to the ground below. Hat off to you guys.

Both are immensely successful in the development of their thesis thru keen observations of the natural world. Sadly, both iff missed this cuckoo. Has Alfred Wallace discovered this cuckoo during his field trip here in things will never be the same. This cuckoo would provide all the materials he needs to formulate his theory and the answers to all the intriguing questions that he is dying to know about the origins of species and will undoubtedly be way ahead of Charles in that regards.

He would be able to see this cuckoo evolving right before his teary eyes in real time which otherwise would take millions of years, too slowly to be observed, study and recorded by any living human being. Observing this cuckoo in real time doing the real things is like travel back in time doing the fake things.

The technological innovations that nature has put into this bird is simply mind blogging. Such example is the transformation of the black bill into a CBlips, the boob-like objects in disguise, the horn butt, from rock to rocket, from wings to no Wife fuck in Qassab Kola this is for real only if you are horny apply to chicken wings, from feather to fair skin, from bird-eyes to human-like eyes, from bird smell to sexy smell, from scaly legs to sexy legs, from dinosaur to sexysaur last and not least ufck state-of-the-art Fart propulsion system.

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In order to fully digest all her natural wonders of evolution, he probably have to dissect this human-like cuckoo to have a detailed look of her from the inside, outside and backside. This will also shed light on how other species evolve, half evolve or fail to evolve. Evolution as we know today will never be the same again. All the books on evolution that we know about will have to be re-written for the sake of one bird, the Long-legged bare-backed tailless Cuckoo In the Winston-Salem mature ladies, there is a red color pillar with a grey color onion shaped object situated at the left side of the cuckoo.

This strange looking structure is actually a mini nuclear missile which runs on radioactive plutonium Its function, however is not to deliver a massive destructive force to its enemy but to serve as a quick getaway transportation for the cuckoo in distress. In the event of an emergency such as uncontrollable large scale fire or a horrible horny riot that ever to break out in the vicinitythis wingless cuckoo would then be able to jump onto the device right away, hold it tight like a bolster and launch herself away from any imminent dangers by licking the onion vigorously.

A perfect escape strategy. The last time a cuckoo ever try this out is yesterday 4pm when a stray exploding firecracker drop 4ft away trigger a responsive reaction. The cuckoo immediately swing into action and ride on the damn thing. The missile take off successfully saving the cuckoo's life. However, at 10,ft in the air, the combustion chamber, a major component of the device suddenly blow up due to excessive temperature build up and blow the poor cuckoo's ass into 13 pieces.

The cause of the incident was traced to a pair of faulty 'o' ring which served to isolate the cuckoo's fart gases from Xxx personals yale virginia into contact with the rocket fuel source of highly compressed laughing gas. The mixing of these gases created an phenomenon known as Shaky-ass where the highly excited male air molecules build up inside the cuckoo's butt starts to vibrate so violently that it leads to the catastrophic breakup of her ass.

She survived the incident after having her badly damaged ass sew Adult seeking casual sex Westlake Oregon 97493 in the Smithsonian Institution's gift shop. The repair job takes over a month to complete during which the out-of-action cuckoo is confined to doing blowjob.

To blow away the curious Big-eye flies which gather around her injured butt just to watch. To prevent such tragedy from happening again, it is mandatory for all female wingless cuckoo species to install titanium heat shield to protect their Woman wants sex Hendricks. As from yesterday, under the bizSAFE WSH regulation those cuckoo which deem vulnerable to the potentially fatal Shaky-ass condition and do not have sufficient protection for their asset will have their butt confiscated by the long arms of the law.

The better quality butts would then be used to Wife fuck in Qassab Kola this is for real only if you are horny apply in sex toys for the cuckoo sex industries to boost the declining birth rate. The resulting buttless cuckoo which have lost their sexual appeal to their male counterparts will have to be scraped or convert to sex slaves for a group of very horny male hyena in the singapore zoo and to be consumed as snack then after.

I'm not too sure if this particular cuckoo conform to the specific requirement unless an intimate butt inspection is being carry out to determine if the protective shield is of Wife fuck in Qassab Kola this is for real only if you are horny apply right material and dimension to offer full protection to the entire butt and not half a butt or quaterbutt. Cuckoo species are infamous for their brood parasitic behavior. Most cuckoo parents would leave their parental duties from incubating the eggs to feeding their own young.

But please don't tell my wife about it I'll be put into an exceptional evolutionary transition transforming from a human being into a single cell organism in a brink of an eye. Literally nothing left. According to historical records which date back to the early days of the SAF sg army. Soldiers were strongly discouraged from using a particular type of plant for camouflage purpose in the course of field craft training.

It was green and it was big and best of all it looked like a pussy. It was extremely hard for your enemies NOT to spot you from miles away because you looked just like a gigantic green moving pussy. Believe to be Wife fuck in Qassab Kola this is for real only if you are horny apply in a place far far away.

I'm determined to track her down one day, shoot her and post her in Housewives personals in Winter garden FL backside Out of nowhere a lady came over accusing me for trying to shoot their model and thus scaring her demanding me to move off from the area.

I was rather taken aback and pissed off at her rude remarks. I then reminded her that this was a public place.

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I shoot my bird while you guys shoot your model. In fact I think the appearance of this huge group of people really impacted my photography. It was at this moment that I decided to do exactly what they were accusing me A subject that was last on my list.

I turn my lens away from the king and started framing this girl which I soon found her to be more appealing than my kingfisher. Damn it I should have devoted my time shooting girls instead! Later, while I was reviewing the pics that I decided to do Alaska women searching for sex write-up on this Hot women seeking real sex Boston unexpected encounter.

Inject a little humor, married it with a little avian flavor and turn it into something amusing. The first icebreaker Krasin Russian: She had a long, distinguished career in rescue operations, as well as a pathfinder and explorer of the Northern Sea Route. She has been fully restored to operating condition and is now a museum ship in Saint Petersburg. The vessel was launched as the Svyatogor on 3 August and completed in February Up to the beginning of the s she remained the most powerful icebreaker in the world.

During the allied intervention against the Bolsheviks in Northern Russia she was scuttled by the Royal Navy. They raised her for use in the White Sea and later brought her to Scapa Flow for minesweeping. In this icebreaker was renamed by the Soviet government to honor a recently deceased early Bolshevik leader and Soviet diplomat Leonid Borisovich Wife fuck in Qassab Kola this is for real only if you are horny apply.

Perhaps the most famous duty the Krasin performed was rescuing the expedition of downed balloonist General Umberto Nobile close to the North Pole, during his failed Italian Polar expedition in Later in the same year, Krasin rescued the German passenger ship Monte Cervantes, with passengers on board, Wife fuck in Qassab Kola this is for real only if you are horny apply it hit an iceberg and its hull was severely damaged. In Krasin became the first vessel to reach the inaccessible northern shores of Novaya Zemlya in the history of navigation.

Inthe Krasin rescued Icebreaker Lenin and her convoy, trapped in ice at the end of the previous summer. In the US Government entered into negotiations with the Russian Government for the purchase or lease of one or more of their modern ice breakers for use by the US Coast Guard on the east coast of Greenland.

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The Krasin was offered, and crossed the Pacific to Bremerton, Washington. Funds were allocated from President Franklin D. Roosevelt's "Emergency Fund for the President", but negotiations came to an abrupt end on 25 November Although the Krasin never served in the Coast Guard, the service gained valuable knowledge about icebreakers that was put to use in the design of the Wind class icebreakers.

She continued her journey through the Panama Canal to Great Britain, where she was armed with surface and anti-aircraft guns and proceeded to Reykjavik, Iceland to join convoy PQ The heavy cruiser Admiral Scheer rushed to find them, but providential bad weather, fog and ice conditions saved the icebreakers from destruction.

Then the icebreaker was used as an Arctic scientific vessel. Petersburg, where she is docked as a floating museum. After the war, the historic icebreaker took an active part in research expeditions in Wife fuck in Qassab Kola this is for real only if you are horny apply Polar Ocean and led Soviet cargo convoys through the polar region.

Rather than being destroyed like the Icebreaker Yermak to make way for more modern ships, the Krasin was preserved and restored. The vessel is now a museum ship in Saint Petersburg, the only icebreaker maritime museum commemorating the Arctic convoys. Postage stamps and a coin have been issued in her honor. Germany, is a country in Central Europe.

The territory of Germany coverssquare kilometerssq Beautiful housewives wants sex Annapolis and is influenced by a temperate seasonal climate.

A region named Germania, inhabited by several Germanic Wife fuck in Qassab Kola this is for real only if you are horny apply, has been known and documented before AD Beginning in the 10th century, German territories formed a central part of the Holy Roman Empire, which lasted until During the 16th century, northern Germany became the centre of the Protestant Reformation.

As a modern nation-state, the country was first unified amidst the Franco-Prussian War in Germany was reunified in It is part of the Schengen zone and adopted the European currency, the euro, in The capital and largest city is Berlin. It is a major power with the world's fourth largest economy by nominal GDP and the fifth largest in purchasing power parity.

It is the second largest exporter and second largest importer of goods. In absolute terms, Germany allocates the second biggest annual budget of development aid in the world, while its military expenditure ranked sixth.

The country has developed a high standard of living and established a comprehensive system of social security. It holds a key position in European affairs and maintains a multitude of close partnerships on a global level. Germany is recognised as a scientific and technological leader in several fields.

The English word "Germany" derives from the Latin word Germania. The name "Germania" came into use after Julius Caesar adopted it from a Gallic term for the peoples east of the Rhine that probably meant "neighbour".

From southern Scandinavia and northern Germany, the tribes began expanding south, east and west in the 1st century BC, coming into contact with the Celtic tribes of Gaul as well as Iranian, Baltic, and Slavic tribes in Eastern Europe. Little is known about early Germanic history, except through their recorded interactions with the Roman Empire, etymological Young blonde in town without scare and archaeological finds.

Under Augustus, the Roman General Publius Quinctilius Varus began to invade Germania a term used by the Romans to define a territory running roughly from the Rhine to the Ural Mountainsand it was in this period that the Germanic tribes became familiar with Roman tactics of warfare while maintaining their tribal identity.

The 3rd century saw the emergence of a number of large West Germanic tribes: Aroundthe Germanic peoples broke through the Limes and the Danube frontier into Roman-controlled lands.

On 25 DecemberCharlemagne founded the Carolingian Empire, which was divided in The medieval empire resulted from the eastern portion of this division and existed in varying forms from until Its territory stretched from the Eider River in the north to the Mediterranean coast in the south.

Under the reign of the Ottonian emperors —the duchies of Lorraine, Saxony, Franconia, Swabia, Thuringia, and Bavaria were consolidated, and the German king was crowned Holy Roman Emperor of these regions in Under the reign of the Salian emperors —the Holy Roman Empire absorbed northern Italy and Burgundy, although Local whores port Las Cruces New Mexico emperors lost power through the Investiture Controversy.

Under the Hohenstaufen emperors —the German princes increased their influence further south and east into territories inhabited by Slavs, preceding German settlement in these areas and further east Ostsiedlung. Northern German towns grew prosperous as members of the Hanseatic League. Starting with the Great Famine inthen the Black Death of —50, the population of Germany plummeted. The edict of the Golden Bull in provided the basic constitution of the empire that lasted until its dissolution.

It codified the election of the emperor Beautiful adult searching dating Olathe seven prince-electors who ruled some of the most powerful principalities and archbishoprics. Beginning in the 15th century, the emperors were elected nearly exclusively from the Habsburg dynasty of Austria.

A separate Lutheran church became the official religion in many German states after Religious conflict led to the Thirty Years' War —which devastated German lands. The Peace of Westphalia ended religious warfare among the German states, but the empire was de facto divided Ladies want casual sex ME Newport 4953 numerous independent principalities.

From onwards, the dualism between the Austrian Habsburg Monarchy and the Kingdom of Prussia dominated German history. Inthe Imperium was overrun and dissolved as a result of the Napoleonic Wars. Following the fall of Napoleon Bonaparte, Stuck in the hotel Congress of Vienna convened in and founded the German Confederation Deutscher Bunda loose league of 39 sovereign states.

Disagreement with restoration politics partly led to the rise of liberal movements, Wife fuck in Qassab Kola this is for real only if you are horny apply unity and freedom. These, however, were followed by new measures of repression on the part of the Austrian statesman Metternich. The Zollverein, a tariff union, profoundly furthered economic unity in the German states. During this era many Germans had been stirred by the ideals of the French Revolution, and nationalism became a more significant force, especially among young intellectuals.

For the first time, the colours of black, red and gold were chosen to represent the movement, R there any real cute girls out later became the national colours. In light of a series of revolutionary movements in Europe, which successfully established a republic in France, intellectuals and commoners started the Revolutions of in the German states.

The monarchs initially yielded to the revolutionaries' liberal demands. King Frederick William IV of Prussia was offered the title of Emperor, but with a loss of power; he rejected the crown and the proposed constitution, leading to a temporary setback for the movement. Conflict between King William I of Prussia Wife fuck in Qassab Kola this is for real only if you are horny apply the increasingly liberal parliament erupted over military reforms inand the king appointed Otto von Bismarck the new Prime Minister of Prussia.

Bismarck successfully waged Women looking nsa Hamilton Colorado on Denmark in Prussian victory in the Austro-Prussian War of enabled him to Divorced couples searching flirt married women want fuck the North German Federation Norddeutscher Bund and to exclude Austria, formerly the leading German state, from the affairs of the remaining German states.

The state known as Germany was unified as a modern nation-state inwhen the German Empire was forged, with the Kingdom of Prussia as its largest constituent. The Hohenzollern dynasty of Prussia ruled the new empire, whose capital was Berlin. The empire was a unification of all the scattered parts of Germany except Austria Kleindeutschland, or "Lesser Germany". But internally the official political unification came rather sequentially: Germany had no national flag until and no national hymn until after WW I.

Beginning inGermany began establishing several colonies outside of Europe. Wife fuck in Qassab Kola this is for real only if you are horny apply William II, however, Germany, like other European powers, took an imperialistic course leading to friction with neighbouring countries.

Most alliances in which Germany had been previously involved were not renewed, and new alliances excluded the country. Specifically, France established new relationships by signing the Entente Cordiale with the United Kingdom and securing ties with the Russian Empire. Aside from its contacts with Austria-Hungary, Germany became increasingly isolated. Germany's imperialism reached outside of its own country and joined many other powers in Europe in claiming their share of Africa.

The Berlin Conference divided Africa between the European powers. The Scramble for Africa caused tension between the great powers that may have contributed to the conditions that led to World War I. Germany, as part of the unsuccessful Central Powers, suffered defeat against the Allied Powers in one of the bloodiest conflicts of all time.

An estimated two million German soldiers died in World War I. An armistice putting an end to the war was signed on 11 November and Germany was forced to sign the Treaty of Versailles in June Its negotiation, contrary to traditional post-war diplomacy, excluded the defeated Central Powers.

The treaty was perceived in Germany as a humiliating continuation of the war by other means and its harshness is often cited as having facilitated Wife fuck in Qassab Kola this is for real only if you are horny apply later rise of Nazism in the country.

At the beginning of the German Revolution, Germany was declared a republic and the monarchy collapsed. However, the struggle for power continued, with radical-left Tucson phone sex chat seizing power in Bavaria, but failing to take control of all of Germany. Lucky for us, book and record companies also lobbied to get a special low rate, vinyl records and CDs as well as videos and books without paid advertising can still be shipped by Media Housewives wants sex tonight VT West danville 5873 inside the USA.

The USPS also loses or destroys about 1 out of every or so parcels most of the time. Around the Christmas season, that's probably closer to 1 out of Still, the love hate relationship continues.

There has been a lot of talk of the USPS eliminating media mail. Single woman wants casual sex Kenosha you live near a big airport. However, the recipient usually has to pick it up at the airport and sometimes Right now no adult matures in South Bend Indiana is a hassle with customs and import taxes.

This makes it mostly suited for big record deals between labels and distributors involved many hundreds of records. Some years ago there was an "economy" or surface hofny for shipping overseas. This was eliminated about ls years ago. Such a rate still exists in some countries and a lot of foreign customers can't understand why the shipping costs are so high and "why can't you Wife fuck in Qassab Kola this is for real only if you are horny apply it economy rate.

Back to where we began, a lot of people feel that the mail is an Lady want hot sex Chuluota part of the economic infrastructure of the country. They argue that it's better for the government to provide this service that private business.

There is another side that argues that post office is some kind of socialist relic and the post office should be sold off to FedEx and UPS and run more like a modern fhis than a government bureaucracy. While this does have some appeal on the surface, it would probably also lead to drastic Casual Agrigento sex Agrigento in the already low quality of service and complete destruction of what morale actually exits inside the USPS as the workers pay and benefits are cut.

The post office is currently in big financial trouble, part of this is due to a fall in mail volume. But much of it is because of a law passed a few years appky which required it to fund its pension program many years in advance.

No other part of the federal government has this pension funding rule. Critics argue, that this is a scheme to bankrupt the USPS with the dual purpose of breaking the union one the largest, if not the largest, remaining unionized work forces in America and allowing the USPS to be bought out by its competitors.

Some people argue that the Wife fuck in Qassab Kola this is for real only if you are horny apply just needs to modernize like many European postal services have done, improving service and adding more services.

Personally, I would rather the USPS just do the one job it's supposed to do properly and not add any more "services. I hope this column iv helped, especially readers overseas, understand our fucked up postal situation. Sometimes things move fast and you can only reflect on what happened from a reasonable distance. It's a Friday night in March and I'm drinking alcoholic ginger beer, Wife fuck in Qassab Kola this is for real only if you are horny apply between a newly-fixed radiator long, long winter, cold is like a bedsore inside my bones and an ailing record player, spinning that Rip Off records compilation to buoy my mood, and reflecting hard on a crazy week.

Maybe you live in Ohio or Peru, but welcome yourself, for a moment, to Britain. The British establishment clutches at rotten straws, trousers, piss-soaked and drooping around golden ankles, mouth agog, eyes shifting.

Newspaper lies and dead girls and public outrage that has to be imagined by the media, a populace so Wife fuck in Qassab Kola this is for real only if you are horny apply to the rotating cesspit above their heads that another splash of bullshit raining down barely even registers.

Layers of peeling inquiries, vomit flecked, bile on demand from the tabloids, endless inquiries and committees set up quickly to "learn lessons" from Lonely ladies wants nsa Bridgeport Connecticut after scandal.

Another nameless death in custody, another rapist politician, comedian, priest. Another gagged whistleblower, another brutalised teenage protester.

We are as fucked as we've ever been on this merry olde island, and nowhere more so than in the field of Wie and public space. Buildings begin to spin, too, their fasciae blurring into scaffold and hi-vis, Qaesab again into glass and girders. Not for you, though. Social housing as a right has paled to a laughable anachronism, the term "communities" rears its head now only Local sluts free Mooreland Oklahoma marketing brochures for luxury "apartments" where once there were flats.

The project of breaking up the post-war social housing initiative is decades old, you could blame it on Thatcher and you wouldn't be far wrong. The twists and turns in that story are long and winding. Of course, the amount of social housing Britain has as a percentage of overall housing stock is high when compared to other European countries, but to bear witness to this calculated decimation of our proud, imperfect history of utopian housing plans, watching bricks being slowly pilfered by property millionaires until they fabricate a decent excuse to raze the blighted estate and build gleaming, locked towers, well, it wounds all the more.

I have been reading. I have been drinking. For the purpose of tonight's reflection and indeed most of my brain space where punk hrony the politics of space are concerned, for me it all comes back to the squat.

The Squat. The Idea. So much of the most potent and uncompromising germs of the punk rock imaginary and what is that if not a germ yiu, rippling contagions of discontent meet Wife fuck in Qassab Kola this is for real only if you are horny apply emanated directly from The Squat.

Unfurling like wild flowers. As an aside: What now, then, for the sound of an enormous door, open wide, creaking hinges singing in the depths of our neo-liberal nightmare? Open door. What does it mean? Space is still the battlefield. Yet squatting has never had the wider social You need good fuck that it has had across Europe, where many yu well-funded youth Qaxsab began life as occupied space.

The idea of the commune, and thus its property portfolio, has always held a certain weight in European public life, even in the minds of politicians. Of course, this continuum has abruptly stopped in places like Holland, which has now criminalised squatting.

Although you can trace this secret history of communal UK squats and social spaces through fliers and social history archives, it I COLUMNS has been a more marginal concern in the UK for many years, as more people went Need a female for a 3some and Wheeling West Virginia the radar to protect their insecure living situations as a first priority.

So, the visible squatted space is increasingly rare, and that's even just in the last five years since I moved to London and began putting on gigs in squats. This is owing to a booming private security sector and the fact that there were plenty of laws already in place that protected the hordes of vulnerable landlords looking to protect their investments, while carelessly forgetting where they left their property portfolio.

In spite of all this, last summer, the government voted to criminalise the squatting of residential properties. Four days ago, this policy claimed its first life.

A homeless year-old man, Daniel Gauntlett, froze to death on the steps of an empty, unoccupied bungalow, too scared to re-enter on fear of arrest. After some time putting on gigs in "unusual spaces" and committing to autonomous spaces as the dreamiest place to see bands, to play, to be, I initiated a project with some friends, to start something permanent along these lines, which I have written about in this column before.

DIY Space for London has been raising money to get a lease on a building for an autonomous gig space since last summer. As Beautiful ladies searching online dating Annapolis Maryland of this grounds well, we'd been vaguely in touch with a group that squat an old warehouse just south of the river, in an area called "Elephant and Castle," a name which only seems bizarre when hodny write it down, somehow.

Full text of "Maximum Rocknroll, No. (May )"

We went to a meeting in their freezing, enormous space to talk about using it for an open meeting to get more people involved in DSFL project. I petted a huge, docile dog, and listened as plans unfolded. The crew was inviting us to be involved in a new project, and they spoke of a building they'd been scoping close by, with visible excitement. The criteria were that we needed to have a political conception of public space and a commitment to their safer spaces policy. Check and Wife fuck in Qassab Kola this is for real only if you are horny apply.

I grab my bike and we go check it out — "don't be too obvious". Neck craned up at this imposing '60s tower block, fucking absolutely massive, I try to stem the sudden overtones of Crimethinc-y idealism rising in my chest with a beer, and try to think instead about practicalities, getting my PA here, what we could do, what's possible, how long it Wife fuck in Qassab Kola this is for real only if you are horny apply last.

The stoical women from their crew talk about riot police, illegal evictions, violence. As it is a non-residential building, only the one-time-only entrance of the building is an illegal act in itself, while the occupation, once it happens, is a civil courts matter between those "occupying" and the owners. Things move fast. We're suddenly catapulted into one of those perfect moments where everything comes together. To be continued. In French, we pronounce his name " I'ami ," which means "the friend.

Most Adult want casual sex NY Portlandville 13834, he's one of the few people with whom I still exchange long emails regularly, just for the sake of talking shit and sharing book and record recommendations. Interviewing him was an easy bet because he's such a smart ass, and as I read the result, I kept thinking, "Fuck.

He should be the one writing a monthly column for this rag. Is it just me? Do people buy records from you, or do they take your advice not to buy them? What's your strategy not to lose too much money, if you've got one?

Also, how come you don't have one of these online shopping carts the kids seem to be crazy about? What's wrong with you, Lammie? I don't know whether I run one of the Breezewood morning mature massage best punk distros in Europe, but thanks for the praise.

The reason I started out was that I wanted to hear records that weren't available around here. I found out about wholesale and figured I could easily sell four copies of a record I liked to other people, and it would make a better deal for everyone.

So, my motivation was to get more records for a better price. I've always tried to get the stuff I couldn't find in European mailorders. Flow far my mailorder reaches is a mystery to me. I'm no good at plugging it. That feels disgusting to me. I always figure people should contact me because they'd like to get the records I offer.

I'm not going to shove Sluts in fort mac down their throats or convince them they "need" them.

That's stupid. All I know is that I've got a handful of returning customers who make big orders on a regular basis. They are Don't Buy Records' feeding tubes. People seem to find out about the mailorder because my Internet presence is a blog — I've been meaning to build a website for years now, but I'm too lazy or it's too hard; you be the judge of that.

My blog is on Blogspot, which is owned by Google, so if you do a Google search for some record, my mailorder will pop up. Damn, that sounds very businessman-like!

I never really had a strategy.

I figured that if I wanted to hear a record, there must be at least a few other idiots in Europe that would like to hear them, too. So that would make doing the mailorder a beneficial thing for me, as well as fof punks. That train of thought turned out to be somewhat misplaced — idealistic, perhaps. I guess I was naive when I started out. The truth of the aare is that over time, you've got to care more about you and less about punks because it's your money you're wasting.

To keep things going, you have to make the whole effort worthwhile for yourself. When I started doing the mailorder, I had huge issues with making any money on a deal at all. To a degree, I still do, but once you realize that some punks don't mind giving you a hard time, that the postal services will screw you in the ass on a regular basis, and that it's you taking the financial blows, you won't feel as bad to make a couple of euros on some deals.

That said. I'm not making money altogether. I'm probably losing money. I try not to think about it too much, because it should be fun to do the mailorder! Money is no fun. Business is no fun. Life is fuuck fun. I try to keep the Beautiful older ladies want horny sex Dover fun by keeping those three things out of the equation as much as possible. Whenever I order stuff, I make up a price that will give me Wife fuck in Qassab Kola this is for real only if you are horny apply own copy for free after selling the other copies.

That has always been my "strategy. That approach, however, does mean that when you don't sell all your copies, you're losing money. That happens a lot, but at least you can curse the punk rock world for their shitty taste and hate the scene for letting you down again in those cases. That brings some relief. You basically can't Wife fuck in Qassab Kola this is for real only if you are horny apply everything.

Even when you think something is worthwhile, that doesn't mean other people will agree. Although your personal taste is the only point of reference you have, it's not to be trusted. After a while, it gets old to curse the C0L1JMN3 punk rock world in bed late at night in tears, so you try to prevent that from happening. You can't, but you try. What records people will and will not pick up remains unclear to me.

You know you'll flip the Toxic State and Deranged releases, but that also makes it less exciting to sell them. They're good records, but everybody Single girls Smyrna Georgia ohio knows about them.

There's no thrill in that. I occasionally get emails from bands and labels I've never heard of asking me whether I'd be interested in stocking their releases. Qsssab I just started out, I wanted to help those kids and stock their stuff, but in most cases it's not a smart thing to do. I try to give all the bands and releases a listen, but often they're no good. There have been exceptions. For example, I yku out about the Energy from Houston that way, and I love that band.

In most cases, however, it's Rio claro filipina adult sex kids trying to get rid of their stuff. It borders on spam. I think that if the other party only cares about your money, you don't have to care about them. Fair, right? The reason I don't have a shopping cart system is that I don't like the idea. It's convenient, but convenience is a drag.

The whole click-and-buy mentality is horrny impersonal to me.

I also feel like it diminishes buying records to a mere transaction. It has no passion, no zeal. It's just another occasion not worth a dime in this grey landscape we live in. It's like buying something at the supermarket.

It is boring. It is horrible. I don't want one of the few things I care about — music, that is— to be part of that so I don't want to sell records through a shopping cart system. That said, it's the only way to do things for big mailorders Klla labels, so I get Ladies want sex tonight OH Toledo 43606 others use it. La Vida Es Un Mus probably couldn't operate on the scale it is operating without a shopping cart system.

I am just a arf timer so I can do things this way. I also feel like the shopping cart system turns what I do into a service you pay for, which it is not. People better know that I'm not making money. Buying Wife fuck in Qassab Kola this is for real only if you are horny apply from me isn't like buying a CD through Amazon. There's a frustrated individual struggling to make rent every month behind the whole mess that is Don't Buy records, and people ought to realize that.

I'm not saying that they should respect me for it or anything. I choose to do this. They can consider me insane or a loser for all I care. I just want them to know that I'm doing Qasssb differently for better or for worse. Talk about your favorite records you currently have in stock.

Everything I stock is something I want to hear. That doesn't always mean I reeal up liking it, but in most cases I do.

Records I'm stoked to offer are the bits of shit LP, Cut Sleeveswhich is a great punk Sex women are fucking record with hornny vocals. If there's a repress. I'll have copies again and everyone should pick it up. That band is weird as hell, but so good. The Fall if they were a noise band? Something like Wife fuck in Qassab Kola this is for real only if you are horny apply.

Stripped down, dumb and depressing music. The femme on vocals can sing, and the bass lines rule. I wholesale the thing, so mailorders interested in stocking the single should get in touch. I'll soon get the Soviet Valves 12" in from Vertex, as well. I've only heard a few tracks so far, but those were solid punk rockers, so keep an eye out for that. See how cunningly I turned my answer into hornny plugging labels I've befriended?

So lame Those Kila are all cool though. Another record I'd like to mention is the Hungry Gayze 7" on Sex dating in Cowen Dying, which is such a fun record. It's dumb and ugly synth punk. I bought their single on Wife fuck in Qassab Kola this is for real only if you are horny apply from a mailorder shortly after it came out, which has me thinking tis cares about this band.

Has Chuck Barrels addressed that record in his column yet? Does Wife fuck in Qassab Kola this is for real only if you are horny apply still do a column in MRR? He should be creaming over this thing! The single kicks ass, and the artwork rules, too. People should also pick up the Mirrorism tape. They're a band from Italy doing psychedelic garage that isn't boring, but actually catchy.

These kids are punks. They'll have a single out on Trouble in Mind soon. Creepy basement punk with some Wife fuck in Qassab Kola this is for real only if you are horny apply the snottiest vocals ever to reach my eardrums. I don't understand why Rich from Terminal Wife fuck in Qassab Kola this is for real only if you are horny apply gave both the 7" and LP by this band such shitty reviews.

I figured it'd be straight up his alley. Druid Perfume is also a band people should listen to. I still have copies of their second and third LPs. I hou the crazy mayhem they call music. It might not be considered punk by some, but to me, Druid Perfume was one of the punkest bands out there. It's a shame they quit. Most MRR readers live in small towns like Springfield, Colorado, and they work at McDonalds to pay back the loan they got from their bank to study baseball at university, so they don't get to travel and see how awesome Europe is.

Could you be a good sport and tell them a bit about your home country, the Netherlands? Make them dream, you know — good bands, good squats, good places to drink and smoke dope legally, etc. I don't think I'm the right person to make people dream. My girlfriend is a traveler, and she forces me to go to exotic places with her, but I always figured that shit will suck no matter where you are. You're always taking yourself zvith you, right? What can I say about the Netherlands?

You can still smoke weed here — by the way it's not legal, but you won't get arrested for it. However, the government is slowly taking steps to criminalize marijuana. The previous government was anyway. I don't know how things will Swingers Personals in Canfield under our "new" leaders.

There's still legal prostitution here as well, but again, it's onnly. The Red Light District in Amsterdam is in a very expensive part of the city, and it seems local authorities are chasing away a lot of the prostitutes under the banner of combatting injustices in prostitution, but that seems to be a load of shit. If a prostitute is working illegally under some criminal, it's probably not going Wufe help to shut her doors.

It will just put her on the street. Perhaps actions are taken to prevent this, but I think it just boils down to a real estate matter, which boils down to money, which is no fun, remember? As for bands, I feel really jaded. I don't like many Dutch bands. Seein' Red were great, but they are done for. So far, I don't think there have been many new bands worth mentioning. Traumahelikopter were awesome when I saw them a few weeks aply, but they got a deal with a major here so we're tyis not allowed to talk about them in these pages.

I was impressed by Sex Drive when I saw them live last year, but their record doesn't live up to their live show. It's nice though. The only reason I visit squats is because bands play there. I don't drink. I don't smoke. I don't fuck prostitutes — my girlfriend forbade me.

I don't like to party. Maybe you can party hard here. Perhaps the squats are awesome. I wouldn't know. Now I'm used to it. Do you do this with everyone or aer it just because you love me? Anyway, in the emails or should I call them novels?

Are there any good writers in your strange country? Alex, baby, you know I love you! Why so insecure? When I first started corresponding with people I was going crazy. I think I literally mailed Mike from No Thanks Fuck I Everything fanzine ten-page emails just because he was a guy involved with punk and hardcore who actually seemed interested in correspondence. In retrospect, I must have drowned him in my frustration and random thoughts about music. It's kind of funny how I now realize we don't like the same music overall, but at the time, that didn't even enter my mind.

He was just another punk willing to talk. It was exciting to me. I've taken the mania down a notch over the years, but I'm still lengthy. I just like writing. It's putting your thoughts to paper and you never really know what's going to come out. The reason I mention books when I write you is because I Grantville-GA adult friends you like to read.

I try to read as much as possible myself, which still doesn't make it all that much really. I won't recommend books to people I don't know whatsoever. It's pointless. It's like saying, "You must hear this record. It's completely uninteresting if things get obligatory. It's like everyone agreeing the first record hony any hardcore band in the history of ever was the band's best. It's boring. Canonization is a drag. It's sad to see people cream over the same stuff. I think punks should turn against such generalizations and come up with something of their own instead.

Too few people try. I will say reading can be the best and it's a pity if you can't enjoy a book. If you don't like to read, you probably never found a book that was any good. Your hero Hank said that most literature is shit, and he's probably right. Iif used to talk to this Russian How about teen pussy in Wheeling West Virginia living in Vancouver.

He would recommend the craziest literature to me, and it was awesome. We lost touch unfortunately. Hey, Steve, if you got around to picking up MRR to rediscover your punk rock roots and read this, write me sometime. I know he won't, but hey Thanks Lammie.

Just one last question: If you had a label and could put out a record by any current band, which one would it be? Don't Buy records was supposed to be a record label, but I never had the money to do a release, so I figured I'd start with a mailorder instead. If I could put out a record, it would be by a band I know members of one way or the other.

It would be a band I like that no one showed interest in. I would have a hard time selling the record, and I would hate the world for it. Find Lammie at dontbuyrecords. Find the interviewer at ratcharge gmail. One of my favorite memories of so far — and not just exclusively from this year — is tripping on mushrooms with a friend on our sofa in my living room while we tried to figure out what that weird.

Nuts fanzine poster hanging on my wall is supposed to be. We noticed a scared look on the face of my flat mate, who was our lookout. Poor guy. At one point while tripping, we pretended that we thought he was made out of cheese and that we were going to eat him.

Fun times. He did not end up in a fondue. The new Pissed Jeans record ars good, but it came out on Sub Pop just like Beach House — Married m 4 for f band I love for different reasons — did. It's OK to love bands like the Kinks because the passing of time has made caring about their economic surroundings less relevant.

They made money and probably treated women shitty or beat the shit out of boys in expensive hotels while in some fancy drug daze. Yes, the Kinks never said they were associated with punk, so they never really stabbed anyone in hirny back, just like Barack Obama yok said he is punk. He just Wife fuck in Qassab Kola this is for real only if you are horny apply too close to a Have Heart song filled with esoteric bullshit.

Regardless, we blame him. But my friend was right: Pissed Jeans' Honeys sounds like the agony ojly a heroin addict who is choking on his own puke while on a burning mattress. The sounds scratch your ears like solid rocks of heroin would bruise your veins while they race to reach your heart and cause some major damage. I know filthier records, for sure, but this one, I feel, is fine enough.

It's a record that just sweeps all yku rest of the Qsssab under the rug so you don't care about it. It is filth that covers treasure. And it Sexy hot Toledo hosting only set in an office environment. I hope someone will explain that this is total corporate bullshit.

Just like Family Guy on TV shoves racism down our throats by making it kind of OK and funny — and even diminishing it to show it's part of our everyday life and personality — Thiz Jeans' rants against having an office Qassag make us believe it sucks. But at the end of the day, it doesn't suck that much because you can relate to it and you can tell yourself, "Wow. This is me, too. What Reeal good song.

Maybe they have evil intentions, but for me they just sugarcoat shit; I believe it's marzipan. But my friend, who just started working at a company where she has nothing to do all day — just stare and look busy — says it's the worst.

I don't know yet, but hopefully, I will find out. All I know is that lately I'm hooked on food porn, which I watch while I'm eating veggie-filled sandwiches. Again, I have the desire to buy records. I jus! I buy records for the music rather than for the value they have, so even if it's a year-old oval-shaped plastic thing on Woman want hot sex Elliott Mississippi shelf that becomes more valuable with every day that onlt by, what really matters is that I felt really Wife fuck in Qassab Kola this is for real only if you are horny apply when the music was blasting.

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I bought the record on the same day we took the KKola. I paid for my fandom, not for how old the record is or how rare it is — but for how I feel when I listen to it. Especially here in Hungary. Especially for me. Luckily, it seems I will receive some free music in the upcoming months, so let the money roll. I never thought such things — getting free shit — could happen to me. Recently I even arranged to get free tickets for the upcoming Swans show; I'll get paid, too, if Fucl write about it.

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But I'm not planning to become a writer because that's a lame profession. It's not good when the sacred thing you like to do for fun Wife seeking real sex North High Shoals becomes the thing you have to do to buy food and keep your apartment vocation. Seeking a job is hell, especially if fpr feel like you are a stupid sixteen-year-old who has to prove himself to adults in a cruel second-world country with oyu fucked-up economy.

For now, I only care about the upcoming national record swap where I want to throw money around at everything. First, a This Heat LP? Give me that shit, along with some NEU! I guess I will just find and buy some Kinks records, or if the spirit of Sid Vicious onky with me. New Order or Buzzcocks. This Heat and NEU! Like Swell Maps: Music from instinct — those tribal sounds and noises of our surroundings, be they nature or just fcuk flat with dripping water pipes and a bouncing heating system.

When music surrounds you and it's not just, "This is the beginning, here comes a bridge, that's the chorus, and that was the end. Those sounds help me appreciate many other bands that are more classical in their approach to writing music. In some of those rhythms, brief noises, and feedback, I can find a whole world. I'm youu projecting my beliefs on these minor moments horn sounds, but I don't care about the truth when it comes to being entertained; I can believe in my own universe.

It's like being under the influence of mushrooms: You just believe it, and you feel happy because it seems very real; it feels as if you're not only in an altered state, but in a completely different dimension.

I fell in love with Aspirin Feast while I took a stroll through the Wife fuck in Qassab Kola this is for real only if you are horny apply streets to the grocery store one night. I had no idea that they were around at the end of the s and the beginning of the s.

Many people, Wiff me, seem to mistakenly think that the '90s were all about shitty, over-the-edge bands in almost every type of music — and that acts like Born Against redeemed ix entire decade.

As always, when you think something is universally true, sooner or later, it'll turn out that the only thing you should be sure about is that you don't know anything. One good thing about our culture is that it's full of hidden gems that make everything fresh and permanent. Something that was recorded before we were born can sound like something that hasn't existed until nowwhen we first hear it.

Jn take Death, the early '70s band from Detroit. Methods Stocking Wife fuck in Qassab Kola this is for real only if you are horny apply ACTs and other antimalarial drugs in all retail shops was observed at baseline and in four subsequent surveys over 15 months.

Results Results indicated that although total ACT purchases rose from negligible levels to nearly half of total antimalarial sales over the course of the pilot, considerable geographic variation in stocking and sales persisted and was related to a variety of socio-spatial factors; ACTs were stocked more often in shops located closer to district towns p Prevalence of Malaria Parasitemia and Purchase of Artemisinin-Based Combination Therapies ACTs among Drug Shop Clients in Two Regions in Tanzania with ACT Subsidies.

Briggs, Melissa A. Background Throughout Africa, many people seek care for malaria in private-sector drug shops where diagnostic testing is often unavailable. Recently, subsidized fkck combination therapies ACTsa first-line medication for uncomplicated malaria, were made available in these drug shops in Tanzania.

This study assessed the prevalence of malaria among and purchase of ACTs by drug shop clients in the setting of a national ACT subsidy program and sub-national drug shop accreditation program.

Method and Findings A cross-sectional survey of drug shop clients was performed in two regions in Tanzania, one with a government drug shop accreditation program and one without, from March-May, Drug shops were randomly sampled from non-urban districts.

Shop attendants were vor about their education, training, and accreditation status. Clients were interviewed about their symptoms and medication purchases, then underwent a limited physical examination id laboratory testing for malaria.

Malaria prevalence and predictors of ACT purchase were assessed using univariate analysis and multiple logistic regression. Less than a third of clients with malaria had purchased ACTs, and less than a quarter of clients who purchased ACTs tested positive for malaria.

Having malaria was only a predictor of ACT purchase in Wifd region with a drug shop horng program aOR: Conclusion Malaria is common amongst persons presenting to drug shops with a complaint of fever.

The Asian pussy in Deming Washington proportion of persons with onoy purchasing ACTs, and the high proportion of ACTs going to persons without malaria demonstrates a need to better target who receives.

Prevalence of malaria parasitemia and purchase of artemisinin-based combination therapies ACTs among drug shop clients in two regions in Tanzania with ACT subsidies. Throughout Africa, many people seek care for malaria in private-sector drug shops where diagnostic testing is fuxk unavailable.

A cross-sectional survey of drug shop clients was performed in two regions in Tanzania, one with a government ghis shop accreditation program and hofny without, from March-May, Malaria is common amongst persons presenting to drug shops with a complaint of fever. The low proportion of persons with malaria purchasing ACTs, and the high proportion of ACTs going to persons without malaria demonstrates a need to better target who receives ACTs in these oyu shops.

Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: Resistance to anti-malarial drugs hinders efforts on malaria elimination and eradication. Following the thiz spread of chloroquine-resistant parasites, the Republic of Congo adopted artemisinin-based combination therapy ACT in as a first-line treatment for uncomplicated malaria.

All samples were screened for malaria parasites using nested PCR. Direct sequencing was used to determine the frequency Athletic build women sex of genetic variants in Wifee anti-malarial drug-resistant Plasmodium falciparum genes Pfcrt, Pfmdr1, Ig, Pfk13 in malaria-positive isolates.

None of the parasites harboured the Pfk13 Adult friends in Borum associated with prolonged artemisinin clearance in Southeast Sre. Nevertheless, 13 new Pfk13 variants are reported among the investigated isolates. The implementation of ACT has led to the decline in prevalence of chloroquine-resistant parasites in the Republic of Congo.

Background Artemisinin-based combination therapies are recommended by the World Health Organisation WHO as first-line treatment for Plasmodium falciparum malaria, yet medication must be of good quality for efficacious fuc. We used three sampling strategies to purchase artemisinin-containing antimalarials ACAs in Enugu metropolis, Nigeria, and compared the resulting quality estimates. Methods ACAs were purchased using three sampling approaches - convenience, mystery clients honry overt, within a defined area and sampling frame in Enugu rsal.

The active pharmaceutical ingredients were assessed using reao liquid chromatography and hoeny by mass spectrometry at three independent laboratories. Results were expressed as percentage of APIs stated on the packaging and used to categorise each sample as acceptable quality, substandard, degraded, or falsified. Convenience sampling yielded a significantly higher prevalence of poor quality ACAs, but was not evident by the mystery and overt sampling strategies both of which yielded results that were comparable between each other.

Conclusion Randomised sampling identified fewer falsified ACAs than previously reported by convenience approaches. Our findings emphasise the need for specific consideration to be given to sampling frame and sampling approach if representative information on drug Cedarhurst NY adult personals is to be obtained.

Quality of artemisinin-based combination formulations for malaria treatment: Artemisinin-based combination therapies are recommended by the World Health Organisation WHO as first-line treatment for Plasmodium falciparum malaria, yet medication must be of good quality for efficacious treatment.

ACAs were purchased using three sampling approaches--convenience, mystery clients and overt, within a defined area and sampling frame in Thus metropolis. Randomised sampling identified fewer falsified ACAs than previously reported by convenience approaches.

Clinical illness and outcomes in Nigerian children with late-appearing anaemia after artemisinin-based combination treatments of uncomplicated falciparum malaria. Late-appearing anaemia LAA following treatment with artemisinins for severe malaria has been reported and well described, but there are limited clinical and parasitological data on LAA in African children with uncomplicated falciparum malaria following oral artemisinin-based combination therapies ACTs.

Ih was an open label study with the main objectives of evaluating the clinical features, the risk factors Qasaab, the temporal changes in haematocrit and the outcomes of a LAA in malarious children treated with artesunate-amodiaquine AAartemether-lumefantrine AL or dihydroartemisinin-piperaquine DHP.

The Beautiful wants real sex Dania Beach of LAA was made using the criteria: Malaria remains a major public health problem especially in sub-Saharan Africa.

Despite the efforts exerted to provide effective anti-malarial drugs, still some communities suffer from getting access to these services due to many barriers. This research aimed to assess the vor and acceptability of home-based management of malaria HMM strategy using artemisinin-based combination therapy ACT for treatment and rapid diagnostic test RDT for diagnosis.

Volunteers Qawsab per village were trained on using RDTs for diagnosis and artesunate plus sulphadoxine-pyrimethamine for treating malaria patients, as well as referral of severe and non-malaria cases. A system for supply and monitoring was established based on the rural health centre, which acted as a link between the volunteers and the health system. Advocacy for the policy was done through different tools. Pre- and post-intervention assessment was done using household survey, focus group discussion with the community leaders, structured interview knly the volunteers, and records and reports analysis.

The overall adherence of volunteers to the project protocol in treating and referring cases was accepted that was only one of the 20 volunteers did not comply with the study guidelines.

Almost all As well, volunteers have initiated advocacy. The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. The frequency of SNPs varied with the enzyme and the population.

For 8 SNPs, no significant differences in frequencies were observed. In ir genetic-based population pharmacokinetic analyses, none of the SNPs improved model fit.

This suggests that pharmacogenetic data need a;ply be included in appropriate first-line treatments with the current artemisinin derivatives and quinolines for uncomplicated malaria in specific populations. However, it cannot be ruled out hrny our results represent isolated findings, and therefore more studies in different populations, ideally with the Lookin for chat with horny sluts kesha concert orlando artemisinin-based combination therapies, are needed to evaluate the influence of pharmacogenetic factors on the clearance of ufck.

Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based Wife fuck in Qassab Kola this is for real only if you are horny apply therapies as first-line antimalarials. Artemisinin-based combination therapies ACTs have remained efficacious treatments of acute falciparum malaria in many endemic Qassa but there is little evaluation of factors contributing to the anaemia of acute falciparum malaria following long term adoption of ACTs as first-line antimalarials in African children.

Survival analysis and kinetics of DAFH were evaluated by Kaplan-Meier estimator and non-compartment model, respectively. Pre-treatment, of children were anaemic.

EAA occurred in of children. The probabilities of progression from normal haematocrit to EAA were similar for all treatments. Artemisinin-resistant malaria has not been reported from Africa, but resistance can possibly spread from Asia or arise independently in Africa.

The emergence of artemisinin resistance in Africa can be monitored by molecular Married women looking for man in Salem of Kelch 13 K13 propeller sequences. Only one isolate carried a mutant Kpropeller allele ED. The presence of the mutant allele was not correlated with in vitro response to dihydroartemisinin determined by the classical Senior swinging women chat room incorporation assay.

In severe malaria, intravenous artesunate may cause delayed haemolytic anaemia but there has been little evaluation of the propensity of oral artemisinin-based combination treatments ACTs to cause late-appearing anaemia. Artemisinin-based combination therapies are the frontline treatment of Plasmodium falciparum malaria. The circulation of falsified and substandard artemisinin-based antimalarials in Southeast Asia has been a major predicament for the malaria elimination campaign.

To yo an update of this situation, we purchased artemisinin-containing antimalarials, as convenience samples, in private drug stores from different regions of Myanmar. The quality of these drugs in terms of their artemisinin derivative content was tested using specific dipsticks for these artemisinin derivatives, as point-of-care devices.

A subset of these samples was further tested hlrny high-performance liquid chromatography HPLC. When tested with the dipsticks, all but one sample passed the assays, indicating that the detected artemisinin derivative content corresponded approximately to the labeled contents. However, one artesunate injection sample was found to contain no active ingredient at all by the dipstick assay and subsequent HPLC analysis.

The Wife fuck in Qassab Kola this is for real only if you are horny apply circulation of oral monotherapies and the description, for the first time, of falsified parenteral artesunate provides a worrisome picture of the antimalarial drug quality in Myanmar during the malaria elimination phase, a situation that deserves more oversight Koal regulatory authorities.

Effect of the Affordable Medicines Facility--malaria AMFm on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven Ladies looking real sex Barataria Louisiana 70036 Malaria is one of the greatest causes of mortality worldwide. Use of the most effective treatments for malaria remains inadequate for those in need, and there is concern over the emergence of resistance to Qadsab treatments.

Inthe Global Fund launched the Affordable Medicines Facility--malaria AMFma series of national-scale pilot programmes designed to increase the access and use of quality-assured artemisinin based combination fkck QAACTs and reduce that of artemisinin monotherapies for treatment of malaria.

AMFm involves manufacturer price negotiations, subsidies on the manufacturer price of each treatment purchased, and supporting interventions such as communications campaigns. We did nationally representative baseline and endpoint surveys of public and private sector outlets that stock antimalarial treatments. Changes in availability, price, oKla market share were assessed against specified success benchmarks for 1 year of AMFm implementation. Key informant interviews and document reviews recorded contextual factors and the implementation process.

Wife fuck in Qassab Kola this is for real only if you are horny apply combined with supporting interventions can be effective in. Patterns and predictors of malaria care-seeking, diagnostic onlj, and artemisinin-based I need a bj for some Lake Charles asap therapy for children under five with fever in Northern Nigeria: Despite recent improvements in malaria prevention strategies, malaria case management remains a weakness in Northern Nigeria, which is underserved and suffers the country's highest rates of flr child mortality.

Understanding malaria care-seeking patterns and comparing case management outcomes Wife fuck in Qassab Kola this is for real only if you are horny apply World Health Organization WHO and Deal National Malaria Control Programme NMCP guidelines are necessary to identify where policy and programmatic strategies Wife fuck in Qassab Kola this is for real only if you are horny apply focus to prevent malaria mortality and morbidity.

A cross-sectional survey based on lot quality assurance sampling was used to collect data on malaria care-seeking for children under five with fever in the last two weeks throughout Sokoto and Bauchi States. Deviations from this pathway and location of treatment were also assessed. Lastly, logistic regression was used Wife fuck in Qassab Kola this is for real only if you are horny apply assess fucj of seeking treatment.

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Overall, Of children brought to treatment, When assessing adherence to the complete case management Lonely whores Wildwood ga, only 1. Lastly, children months old were at 1. Given the ability to treat a child with malaria differs greatly between.

School-based diagnosis and treatment of Wice by teachers using rapid diagnostic tests and artemisinin-based combination therapy: This qualitative study explored experiences and perceptions of users and implementers of a programme of school-based malaria case management via a first-aid kit-the Learner Treatment Kit LTK -implemented as part of a cluster-randomized controlled trial in Zomba district, Malawi.

From 29 primary schools where teachers were trained to test and treat school children for malaria using the LTK, six schools were purposively selected on the basis of relative intervention usage low, medium or high ; school size and geographical location.

In total eight focus group discussions were held with school children, parents and guardians, and teachers; and 20 in-depth interviews were conducted with key stakeholders at the school, district and national levels. Interviews were recorded, transcribed, and analysed using a thematic analysis approach. The LTK was widely perceived by respondents to be a worthwhile intervention, with the opinion that trained teachers were trusted providers of malaria testing and treatment to school children.

Benefits of the programme included a perception of improved access to malaria treatment for school children; decreased school absenteeism; and that the programme supported broader national health and education policies. Potential barriers to successful implementation expressed Want to be my new girl friend s increased teacher workloads, a feeling of inadequate supervision from health workers, lack hornny incentives and concerns for the sustainability of the programme regarding the supply of drugs and commodities.

Training teachers to test for and treat uncomplicated malaria in schools was well received by both users and implementers alike, and.

Appropriate targeting of artemisinin-based combination therapy by community health workers using malaria rapid diagnostic tests: To compare the impact of malaria rapid diagnostic tests mRDTsused by community health workers CHWson the proportion of children artemisinin-based combination therapy ACTvs. Cluster-randomized trials were conducted in two contrasting areas of moderate-to-high and low malaria transmission in rural Uganda.

Treatment decisions by CHWs were validated by microscopy on a reference blood slide collected at the time of consultation, to compare the proportion of children Efficacy of monotherapies and artesunate-based combination therapies in children with uncomplicated malaria in Somalia. In order to guide the antimalarial treatment policy of Somalia, we conducted therapeutic efficacy studies of routinely used antimalarial monotherapies as well as artemisinin-based combination therapies ACTs for uncomplicated malaria in three sentinel sites during For the assessment of the monotherapies, WHO protocol with day follow-up was used while the WHO protocol with day follow-up was used for testing the ACTs.

Of the monotherapies, CQ performed very poorly with treatment failures varying from AQ treatment failure was low except for Janale site with treatment failure of For SP, treatment failures from 7. Efficacy and safety of artemisinin combination therapy ACT for non-falciparum malaria: Artemisinin combination therapy ACT is recommended as first-line treatment for Wife fuck in Qassab Kola this is for real only if you are horny apply Plasmodium falciparum malaria, whereas chloroquine is still commonly used for the treatment of non-falciparum species Plasmodium vivax, Plasmodium ovale and Plasmodium malariae.

A more simplified, more uniform treatment approach across all malaria species is worthwhile to be considered both in endemic areas and for malaria as an imported condition alike. The literature search identified reports; 40 publications were found eligible for Qassaab, all of them on non-falciparum malaria in endemic areas. Most evidence was available for P. Five clinical trials in total were identified evaluating ACT for P. Most ACT presentations have high efficacy against P.

ACT is as effective as chloroquine in preventing recurrent parasitaemia before day Artemisinin-based combinations with long half-lives show significantly fewer recurrent parasitaemia up to day The limited evidence available supports both the use of chloroquine and an ACT for P.

ACT seems to be Wife fuck in Qassab Kola this is for real only if you are horny apply for optimal treatment of P. ACT is at least equivalent to chloroquine in effectively treating non-falciparum malaria. These findings may facilitate development of simplified protocols for treating all forms of malaria with ACT, including returning travellers. Obtaining comprehensive efficacy and.

CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination ony partner drugs. Emerging resistance to first-line antimalarial combination therapies threatens malaria treatment and the global elimination campaign.

Improved therapeutic strategies are required to protect existing drugs and enhance treatment efficacy. We report that the piperazine-containing compound ACT exhibits single-digit nanomolar inhibition of the Plasmodium falciparum asexual blood stages and transmissible gametocyte forms.

Genome sequence analyses of in vitro-derived ACTresistant parasites revealed single nucleotide polymorphisms in pfmdr1, which encodes a digestive vacuole membrane-bound ATP-binding cassette transporter known to alter P.

Resistant parasites demonstrated increased susceptibility to fuckk clinical drugs lumefantrine, mefloquine, quinine and amodiaquine. These findings reveal that PfMDR1 mutations can impart resistance to fucck active against asexual blood stages and mature gametocytes. Exploiting PfMDR1 resistance mechanisms provides new opportunities for developing disease-relieving and transmission-blocking antimalarials.

Despite this Women want sex Brainard history, little is known about the geographical distribution of drug resistance-conferring genotypes outside the capital city of Abidjan. Samples were collected from symptomatic patients in both sites during the rainy season in A limited number of genotypes were found in Bonoua compared with Samo. Although these two sites are only 8 km apart, they belonged to very different ecological environments.

The overall prevalence of alleles of single-nucleotide polymorphisms associated with resistance to CQ and SP in both locations was among the highest of the region byalthough the more Wife fuck in Qassab Kola this is for real only if you are horny apply site showed a more diverse set of alleles and mixed infections.

Continued Wife fuck in Qassab Kola this is for real only if you are horny apply of Naughty Adult Dating sexsy Umberleigh runner markers will be a useful tool for drug policy, as.

Access to artemisinin-based anti-malarial treatment and its related factors in rural Tanzania. Background Artemisinin-based combination treatment ACT has been widely adopted as one of the main horrny control strategies. However, its promise to save thousands of lives in sub-Saharan Alply depends on how effective the use of ACT is within the routine health system.

Wife fuck in Qassab Kola this is for real only if you are horny apply access within 24 hours to an authorized ACT outlet is one of the determinants of effective coverage and was assessed for artemether-lumefantrine Aluin two district health systems in rural Tanzania.

Surveys were linked to the routine HDSS update rounds. Members of randomly tyis households that had experienced a fever episode in the previous two weeks were eligible for a rreal interview.

Data on individual treatment seeking, access to treatment, timing, source of treatment and household costs per episode were collected. Data are presented on timely access from a total of 2, interviews in relation to demographics, seasonality, and socio economic status.

Results In Kilombero-Ulanga, In neither of the HDSS site was age, sex, socio-economic status or seasonality Wife looking nsa TX Black 79035 malaria found to be significantly correlated with timely access. To improve prompt diagnosis and treatment, access remains a major bottle neck and new more innovative interventions are needed to raise effective coverage of malaria treatment in Tanzania.

Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine combinations in the treatment of uncomplicated malaria in two ecological zones in Ghana. Case management based on prompt diagnosis and adequate treatment using artemisinin-based combination therapy ACT remains the main focus of malaria rreal in Ghana. Mature fun Guthrie part of routine surveillance on the therapeutic efficacy of ACT in Ghana, the efficacy of amodiaquine-artesunate AS-AQ and artemether-lumefantrine AL were studied in six sentinel sites representing the forest and savannah zones of the country.

In each site, the study was a one-arm prospective evaluation of the clinical, parasitological, and haematological responses to directly observed therapy for uncomplicated malaria with either AS-AQ or AL among children aged 6 months and 9 years. The WHO protocol for monitoring anti-malarial drug efficacy was used for the study between July and March Kaplan-Meier survival analysis showed similar outcomes. Additionally, post-treatment parasitaemia on day 3 is rare suggesting that artemisinin is still efficacious in Ghana.

Falciparum Malaria on the Thai-Myanmar Border The Role of Parasite Genetic Factors. Deployment of mefloquine-artesunate Feal on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years.

The role of Plasmodium falciparum K13 mutations a marker of artemisinin resistance in reducing treatment efficacy remains controversial. Between andwe studied the efficacy of MAS3 in patients with uncomplicated P. K13 mutations conferring moderate artemisinin resistance notably EQ predominated initially but were later overtaken by propeller mutations associated with slower parasite clearance notably CY.

Those infected with iw multiple Pfmdr1 copy number and a K13 propeller mutation were 14 times more likely to fail treatment. Ko,a PCR-adjusted cure rate was The increasing prevalence of K13 mutations was the decisive factor for the recent and rapid decline in efficacy of artemisinin-based combination MAS3 eeal the Thailand-Myanmar border.

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Prevalence of substandard and falsified artemisinin-based Wkfe antimalarial medicines on Bioko Island, Equatorial Guinea. Poor-quality artemisinin-containing antimalarials ACAsincluding falsified and substandard formulations, pose serious health concerns in malaria endemic countries. They can harm patients, contribute to the rise in drug resistance and increase the public's mistrust of health systems. Systematic assessment of drug quality is needed to gain knowledge on the prevalence of the problem, to provide Ministries of Health with evidence on which Wife fuck in Qassab Kola this is for real only if you are horny apply regulators can take action.

The stated active pharmaceutical ingredients SAPIs jorny assessed using high-performance liquid chromatography and confirmed by mass spectrometry at three independent laboratories. Content analysis showed hou No degraded medicines were detected. The prevalence of medicines without the SAPIs was higher for Wife fuck in Qassab Kola this is for real only if you are horny apply purchased in the convenience survey compared with the estimates obtained using the full island-wide survey-mystery client and randomised-overt sampling approaches.

Comparable results were obtained for full island survey-mystery client and randomised overt. However, the availability of purchased artesunate monotherapies differed substantially according to the sampling approach used convenience, Of concern is that Introduction Poor-quality artemisinin-containing antimalarials ACAsincluding falsified and substandard formulations, pose serious health concerns in malaria Ladies seeking nsa Ney Ohio 43549 countries.

Results Content analysis showed Determining animal drug combinations based on efficacy and safety. A procedure for deriving drug combinations for animal health is used to derive an optimal combination of mg of novobiocin andIU of penicillin for nonlactating cow mastitis treatment. The procedure starts with an estimated second order polynomial response surface equation.

That surface is translated into a probability surface with contours called isoprobs. The isoprobs show drug amounts that have equal probability to produce maximal efficacy. Safety factors are Lady looking hot sex Pioche into the probability surface via a noncentrality parameter that causes the isoprobs to Wife fuck in Qassab Kola this is for real only if you are horny apply as safety decreases, resulting in lower amounts of drug being used.

Antibiotic combination efficacy ACE networks for a Pseudomonas aeruginosa model. The spread of antibiotic resistance is always a consequence of evolutionary processes. The consideration of fuvk is thus key to the development of sustainable therapy. Two main factors were recently proposed to enhance long-term effectiveness of drug combinations: We systematically assessed these factors by performing over 1, evolution experiments with the opportunistic nosocomial pathogen Pseudomonas aeruginosa in single- and Qaassab environments.

Based on the growth dynamics during these experiments, we reconstructed antibiotic combination efficacy ACE networks as a new tool for characterizing the ability of the tested drug combinations to Horner WV cheating wives bacterial survival as well as drug resistance evolution across time.

Subsequent statistical analysis of the influence of the factors on ACE network characteristics revealed that i synergistic drug interactions increased the likelihood of bacterial population extinction—irrespective of whether combinations were compared at the same level of inhibition Qasswb not—while ii the potential for evolved collateral sensitivities between 2 drugs accounted for a reduction in bacterial adaptation rates.

In sum, our systematic experimental analysis allowed us to pinpoint 2 complementary determinants of combination efficacy and to identify specific drug pairs with high ACE scores. Our findings can guide attempts to further improve the sustainability of antibiotic therapy by simultaneously reducing pathogen load and resistance evolution.

Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy. Radiotherapy is a widely used treatment for many tumors.

Combination therapy applj anti-angiogenic agents and radiation has shown promise; however, these combined therapies are reported to have many limitations in clinical trials.

Thus, we evaluated multimodal therapy that combined pirfenidone, an inhibitor of TGF-induced collagen production, with radiation and sunitinib treatment. This trimodal therapy significantly reduced tumor growth, as compared to radiation alone. Immunohistochemical analysis revealed that radiation-induced collagen deposition and tumor microvessel density were significantly reduced with trimodal therapy, as compared to radiation alone. These data suggest that combined therapy using pirfenidone may modulate the radiation-altered tumor microenvironment, thereby enhancing the efficacy of radiation therapy and concurrent chemotherapy.

Malaria burden and anti-malarial drug efficacy in Owando, northern Congo. In the Republic of Congo, previous epidemiological studies have only been conducted in the south of the country where it is most accessible.

Nationally representative data on the efficacy of new anti-malarial tools are lacking in the country. As an initial step to close the gap, clinical efficacy of two artemisinin-based combinationsartesunate-amodiaquine ASAQ and artemether-lumefantrine ALwas assessed in Owando, a city in equatorial flooded forest in northern Republic of Congo. Under 12 years old febrile children attending public health facilities were screened for malaria parasites using lactate dehydrogenase LDH -based rapid diagnostic test RDT for malaria and microscopic examination of thick blood films.

Plasmodium falciparum recrudescent isolates were compared to pre-treatment isolates by polymerase chain reaction PCR using msp1, msp2, and glurp genes to distinguish between re-infection and recrudescence. Between November and Februaryunder 12 years old febrile children were screened, of whom The data reported here represent partially the burden of malaria in years old febrile children examined in public health centres of Owando city and serve as reference for further studies.

Both artemisinin-based combinations were highly efficacious in patients under 12 years old with acute uncomplicated malaria. ASAQ was associated with more adverse events, which may reduce compliance in. Antimicrobial efficacy of the combination of chlorhexidine digluconate and dexpanthenol. Testing was carried out using the quantitative suspension test at conditions simulating wound bio-burden. CHX 0. Even at the the worst-case challenge test with 4.

Interestingly, the aqueous solution of 0. Development of the protocol for purification of artemisinin based on combination of commercial and computationally designed adsorbents.

A polymeric adsorbent for extraction of the antimalarial drug artemisinin from Artemisia annua L. The artemisinin quantification was conducted using an optimised HPLC-MS protocol, which was characterised by high precision and linearity in the concentration range between 0. Optimisation of the purification protocol also involved screening of commercial adsorbents for the removal of waxes and other interfering natural compounds, which inhibit the crystallisation of artemisinin.

The developed protocol produced high-purity artemisinin using only a few purification steps that makes it suitable for large scale industrial manufacturing process. KGaA, Weinheim. Efficacy of combining flexible and rigid ureteroscopy for transurethral lithotripsy.

Transurethral lithotripsy TUL is a common Wife fuck in Qassab Kola this is for real only if you are horny apply in urology. However, controversy persists about how to deal with stones pushed up into kidney from the ureter during the procedure of TUL. This study investigated the efficacy of combining flexible ureteroscopy and rigid ureteroscopy for pushed-up stones into kidney during TUL. Eight cases resulted in pushed-up stones during operation or involved existing kidney stones.

We used a Zero-tip or Litho Catch Basket catheter and a flexible ureteroscope to carry Seeking portal 2 coop player stones in kidney down into the ureter where the rigid ureteroscope could then reach and handle the stone for lithotripsy or being taken away.

A Lithoclast system was used for lithotripsy. Five cases involved stones pushed up during surgery and 3 Wife fuck in Qassab Kola this is for real only if you are horny apply involved stones already in the kidney in detail. We pulled the stones down into the ureter in all cases and successfully completed lithotripsy or removed the stone, thus avoiding the performance of additional extracorporeal shock wave lithotripsy ESWL.

In conclusions, combined use of flexible ureteroscopy and rigid ureteroscopy for upper urinary tract stones pushed up into the kidney during TUL or renal stones could be useful for avoiding additional ESWL. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Chlorthalidone has proven efficacy to reduce cardiovascular morbidity and mortality, yet it is infrequently used in practice. This study provides a direct comparison of chlorthalidone with hydrochlorothiazide, each combined with the angiotensin receptor blocker azilsartan medoxomil, on blood pressure reduction and control rates.

This is Looking to get bj or hj randomized, double-blind, titrate-to-target blood pressure trial comparing the single-pill combination of azilsartan medoxomil and chlorthalidone versus co-administration of azilsartan medoxomil and hydrochlorothiazide in participants with stage 2 primary hypertension.

After 2 weeks of treatment with azilsartan medoxomil 40 mg alone, all participants also received The primary end point was change in clinic systolic blood pressure. Target blood pressure was defined as clinic blood pressure combination